Capabilities
Services
Organized by the outcome you want — not by technique.
01
Full program · Turnkey
Send us a gene. We handle everything else.
One contract, one team, one report. You never handle samples, reagents, imports, or shipping — and for international clients, only data crosses the border. No customs.
- 01
Cell line sourcing
Coriell, ATCC, or client-provided material.
- 02
Reprogramming
Fibroblasts or blood to iPSC.
- 03
Full characterization
Identity, sterility, pluripotency, karyotype.
- 04
Differentiation
To the target cell type.
- 05
Disease phenotyping
Cellular and molecular endpoints.
- 06
Data analysis
Transcriptomic and imaging readouts.
- 07
Final report
Complete dataset, methods, and interpretation.
Capacity — 2 turnkey programs per quarter
How a turnkey program runs
01
Scope and quote
2 business days
You send the gene, variant, and question. We reply with a fixed quote and start date.
02
Cell sourcing and reprogramming
8–14 weeks
Line sourced from Coriell or ATCC, reprogrammed to iPSC, fully characterized and banked.
03
Differentiation and phenotyping
6–12 weeks
Differentiation to the target cell type, then cellular and molecular disease endpoints.
04
Data and report
4–6 weeks
Transcriptomic and imaging analysis. Complete dataset, methods, and interpretation.
Why international clients use us
Importing live cells and reagents means customs delays, cold-chain shipping, and a culture that can arrive non-viable. Contracting the full chain in San Diego removes that — the line is sourced, grown, tested, and analyzed here. What crosses the border is data: a report and raw files, nothing that degrades in transit.
02
Cell models
Build a model
We generate and bank the human cell model you need, characterized to the standard a regulatory reviewer expects.
iPSC reprogramming
From fibroblasts or PBMCs. Non-integrating Sendai / CytoTune.
- Turnaround
- 6–10 weeks
- Deliverable
- 3 clones / donor
Full iPSC characterization
Mycoplasma, sterility, vector clearance, STR identity, pluripotency ICC, endogenous RT-qPCR, trilineage differentiation, karyotype.
- Turnaround
- 4–6 weeks
- Deliverable
- Full QC dossier
Master and working cell banking
Expanded, cryopreserved, and stored. Working banks aliquoted for direct use.
- Turnaround
- 2–3 weeks
- Deliverable
- Master + working banks
Cortical organoids — guided
Three protocols — semi-guided, guided, subpallial/MGE — cultured from 15 to 90+ days.
- Turnaround
- Organoid age + 15–25 days
- Deliverable
- 24–48 organoids + QC report
Ventricular cardiomyocytes
Wnt-modulated differentiation with lactate selection. >90% cTnT+, MLC2v+ subtype.
- Turnaround
- 30 days with immunofluorescence
- Deliverable
- 10M cells, live or cryo
NPC and neuronal cultures
NPC expansion or NGN2 induction. MAP2+/TUJ1+ cultures, MEA-ready plating on request.
- Turnaround
- 30 days with immunofluorescence
- Deliverable
- Plated batches, MEA-ready
CRISPR-corrected isogenic pairs
Disease variant corrected to an otherwise identical control line.
- Turnaround
- 3–4 months
- Deliverable
- Paired lines + edit confirmation
03
Modality-agnostic screening
Screening program — any modality, patient-derived human tissue.
Our product is the human cell model, not the molecule. The cell does not distinguish what it receives.
Request a quote →Modalities
- Antisense oligonucleotides — gapmer, splice-switching, and upregulation designs
- RNA editing oligonucleotides, including ADAR-recruiting guides
- Therapeutic peptides
- Small molecules
- siRNA
Available readouts
- Target engagement by RT-qPCR
- Dose-response and EC50
- Immunofluorescence
- Confocal microscopy
- Immunofluorescence image analysis
- Transcriptome-wide off-target assessment by RNA-seq
- Isoform-resolution readout showing what happened to the full transcript, not just one junction
Most screening is done in HEK293 or reporter lines. Splicing and expression context are cell-type specific — a molecule that works in a generic line may not work in neurons. We screen in the cell type that matters.
04
Computational
Analyze data
All bioinformatics is performed in-house and delivered to clients in any country. No samples required — data in, results out.
Bulk RNA-seq analysis
QC, alignment, differential expression, pathway enrichment. Code and counts matrices delivered.
- Turnaround
- 1–2 weeks
- Deliverable
- Counts matrix + code + report
Single-cell RNA-seq
Ambient RNA and doublet removal, integration, clustering, atlas annotation, compositional testing.
- Turnaround
- 2–4 weeks
- Deliverable
- Annotated object + report
Aberrant splicing detection
Junction-level outlier detection with sashimi plots. Exon skipping, intron retention, cryptic splice sites.
- Turnaround
- 3–4 weeks
- Deliverable
- Event table + sashimi plots
Isoform structure modeling
Long-read or hybrid assembly. Per-isoform abundance and ORF impact.
- Turnaround
- 3–5 weeks
- Deliverable
- Isoform GTF + abundance
Methylation analysis
Array or bisulfite data. DMR detection against controls.
- Turnaround
- 3–4 weeks
- Deliverable
- DMR table + report
Proteomics
Processing and statistical analysis of MS datasets. Differential abundance testing.
- Turnaround
- 3–5 weeks
- Deliverable
- Protein table + report
Whole-genome and exome interpretation
Variant calling review, annotation, and prioritization against the disease hypothesis.
- Turnaround
- 4–6 weeks
- Deliverable
- Ranked variant report
Antisense oligonucleotide design
Across five mechanisms of action. 40–80 ranked candidates per target with off-target screening.
- Turnaround
- 5–10 days
- Deliverable
- 40–80 ranked candidates
Peptide design
Sequence design against a defined target, with predicted properties.
- Turnaround
- 5–10 days
- Deliverable
- Ranked candidates
Target tractability assessment
Literature and dataset review of whether a target supports the modality you have in mind.
- Turnaround
- 2–3 weeks
- Deliverable
- Assessment memo
Published turnaround times
Planning ranges by service
iPSC reprogramming
6 to 10 weeks
Request a quote →Full iPSC characterization
4 to 6 weeks
Request a quote →Cortical organoid production
Organoid age plus 15 to 25 days
Request a quote →Differentiation to neurons, NPCs or cardiomyocytes, with immunofluorescence
30 days
Request a quote →CRISPR editing or correction
3 to 4 months
Request a quote →Karyotype
1 month
Request a quote →qPCR and RT-qPCR
5 days
Request a quote →Sanger sequencing
5 days
Request a quote →Confocal microscopy
1 to 2 weeks
Request a quote →Immunofluorescence image analysis
1 to 2 weeks
Request a quote →ASO or peptide design
5 to 10 days
Request a quote →Bulk RNA-seq analysis
1 to 2 weeks
Request a quote →Single-cell RNA-seq analysis
2 to 4 weeks
Request a quote →Organoid timing varies with the quality of the starting iPSC line.
Single-cell timing depends on sample number.
Turnaround begins when material arrives and the deposit clears.
All cell work, drug screening, confocal microscopy, immunofluorescence image analysis, and bioinformatics are performed in-house. Sequencing and laboratory processing for bulk RNA-seq, scRNA-seq, snRNA-seq, and methylation, as well as karyotyping and digital SNP, are performed by accredited partner laboratories under our coordination. You receive a single Certificate of Analysis and deal with one party.